MED1

Available protein structures:
PDB	IPR019680 PF10744 (ECOD; PDBsum)
AlphaFold	IPR019680; PF10744;

Med1
Med1
Identifiers
Symbol	Med1
Pfam	PF10744
InterPro	IPR019680
PDB
Available protein structures:
PDB	IPR019680 PF10744 (ECOD; PDBsum)
AlphaFold	IPR019680; PF10744;

MED1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1RJK, 1RK3, 1RKG, 1RKH, 2O4J, 2O4R, 2ZFX, 3A2H, 3AUN, 3VJS, 3VJT, 3VRT, 3VRU, 3VRV, 3VRW, 3W0G, 3W0H, 3W0I, 3W0J, 3W5P, 3W5Q, 3W5R, 3W5T, 3WT5, 3WT6, 3WT7, 3WTQ, 5AWK, 5AWJ, 4YNK, 5B5B
Identifiers
Aliases	MED1, CRSP1, CRSP200, DRIP205, DRIP230, PBP, PPARBP, PPARGBP, RB18A, TRAP220, TRIP2, mediator complex subunit 1
External IDs	OMIM: 604311; MGI: 1100846; HomoloGene: 21002; GeneCards: MED1; OMA:MED1 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	39,451,272 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	98,084,119 bp
RNA expression pattern
	Top expressed in
	tendon of biceps brachii; ; nipple; ; visceral pleura; ; lower lobe of lung; ; mucosa of paranasal sinus; ; superficial temporal artery; ; parietal pleura; ; trabecular bone; ; human penis; ; buccal mucosa cell;
	Top expressed in
	Rostral migratory stream; ; cumulus cell; ; spermatocyte; ; spermatid; ; vestibular membrane of cochlear duct; ; hair follicle; ; tail of embryo; ; otic placode; ; internal carotid artery; ; genital tubercle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein-containing complex binding; DNA-binding transcription factor activity, RNA polymerase II-specific; estrogen receptor binding; ubiquitin protein ligase activity; transcription factor binding; transcription coregulator activity; thyroid hormone receptor binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; retinoic acid receptor binding; chromatin binding; LBD domain binding; protein binding; nuclear receptor binding; vitamin D receptor binding; DNA binding; mediator complex binding; transcription coactivator activity; peroxisome proliferator activated receptor binding; nuclear receptor coactivator activity; chromatin DNA binding; RNA polymerase II core promoter sequence-specific DNA binding; transcription corepressor activity; signaling receptor activity;
Cellular component	membrane; nucleus; mediator complex; nucleolus; chromatin; ubiquitin ligase complex; nucleoplasm; protein-DNA complex;
Biological process	regulation of RNA biosynthetic process; thyroid hormone mediated signaling pathway; negative regulation of neuron differentiation; regulation of transcription by RNA polymerase II; monocyte differentiation; embryonic heart tube development; androgen biosynthetic process; epithelial cell proliferation involved in mammary gland duct elongation; enucleate erythrocyte development; animal organ regeneration; angiogenesis; animal organ morphogenesis; regulation of transcription, DNA-templated; negative regulation of keratinocyte proliferation; positive regulation of erythrocyte differentiation; regulation of transcription by RNA polymerase I; ERK1 and ERK2 cascade; in utero embryonic development; mammary gland branching involved in pregnancy; transcription, DNA-templated; positive regulation of transcription, DNA-templated; development of the heart; protein ubiquitination; camera-type eye development; transcription initiation from RNA polymerase II promoter; lactation; cellular response to steroid hormone stimulus; positive regulation of intracellular estrogen receptor signaling pathway; peroxisome proliferator activated receptor signaling pathway; cellular response to hepatocyte growth factor stimulus; positive regulation of keratinocyte differentiation; positive regulation of interferon-gamma-mediated signaling pathway; positive regulation of G0 to G1 transition; embryonic placenta development; negative regulation of apoptotic process; intracellular steroid hormone receptor signaling pathway; negative regulation of transcription by RNA polymerase II; retinal pigment epithelium development; ventricular trabecula myocardium morphogenesis; thyroid hormone generation; fat cell differentiation; positive regulation of hepatocyte proliferation; megakaryocyte development; androgen receptor signaling pathway; positive regulation of mammary gland epithelial cell proliferation; mammary gland epithelial cell proliferation; mammary gland branching involved in thelarche; regulation of vitamin D receptor signaling pathway; mRNA transcription by RNA polymerase II; keratinocyte differentiation; regulation of cell cycle; cellular response to epidermal growth factor stimulus; multicellular organism development; positive regulation of signaling receptor activity; brain development; positive regulation of gene expression; lens development in camera-type eye; cell morphogenesis; embryonic hemopoiesis; cellular response to thyroid hormone stimulus; positive regulation of cell population proliferation; liver development; positive regulation of transcription by RNA polymerase II; erythrocyte development; embryonic hindlimb morphogenesis; regulation of lipid metabolic process; protein import into nucleus;
	Sources:Amigo / QuickGO
Orthologs
	5469
	19014
	ENSG00000125686
	ENSMUSG00000018160
	Q15648
	Q925J9
	NM_004774
	NM_001080118; NM_013634; NM_134027; NM_001361950; NM_001361951
	NP_004765
	NP_001073587; NP_038662; NP_598788; NP_001348879; NP_001348880
	Wikidata
View/Edit Human	View/Edit Mouse

Mediator of RNA polymerase II transcription subunit 1 also known as DRIP205 or Trap220 is a subunit of the Mediator complex and is a protein that in humans is encoded by the MED1 gene. MED1 functions as a nuclear receptor coactivator.