MDMAR

MDMAR
Clinical data
Other names3',4'-Methylenedioxy-4-methylaminorex
ATC code
  • None
Identifiers
  • 5-(1,3-benzodioxol-5-yl)-4-methyl-4,5-dihydro-1,3-oxazol-2-amine
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC11H12N2O3
Molar mass220.228 g·mol−1
3D model (JSmol)
  • CC1C(OC(=N1)N)C2=CC3=C(C=C2)OCO3
  • InChI=1S/C11H12N2O3/c1-6-10(16-11(12)13-6)7-2-3-8-9(4-7)15-5-14-8/h2-4,6,10H,5H2,1H3,(H2,12,13)
  • Key:JFKNBDXNCLMRPL-UHFFFAOYSA-N

3',4'-Methylenedioxy-4-methylaminorex (MDMAR) is a recreational designer drug from the substituted aminorex family, with monoamine-releasing effects. It is a potent serotonin–norepinephrine–dopamine releasing agent (SNDRA).

Monoamine release of MDMAR and related agents (EC50Tooltip Half maximal effective concentration, nM)
Compound NETooltip Norepinephrine DATooltip Dopamine 5-HTTooltip Serotonin Ref
Phenethylamine 10.9 39.5 >10,000
Dextroamphetamine 6.6–10.2 5.8–24.8 698–1,765
Dextromethamphetamine 12.3–14.3 8.5–40.4 736–1,292
Aminorex 15.1–26.4 9.1–49.4 193–414
cis-4-MAR 4.8 1.7 53.2
cis-4,4'-DMAR 11.8–31.6 8.6–24.4 17.7–59.9
trans-4,4'-DMAR 31.6 24.4 59.9
cis-MDMAR 14.8 10.2 43.9
trans-MDMAR 38.9 36.2 73.4
Notes: The smaller the value, the more strongly the drug releases the neurotransmitter. The assays were done in rat brain synaptosomes and human potencies may be different. See also Monoamine releasing agent § Activity profiles for a larger table with more compounds. Refs:
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