MASP1 (protein)

MASP1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3DEM, 3GOV, 4AQB, 4DJZ, 4IGD, 4IW4, 4KKD
Identifiers
Aliases	MASP1, 3MC1, CRARF, CRARF1, MAP1, MASP, MASP3, MAp44, PRSS5, RaRF, mannan binding lectin serine peptidase 1, Mannan-binding lectin serine protease 1, MBL associated serine protease 1, MASP-3, MAP-1
External IDs	OMIM: 600521; MGI: 88492; HomoloGene: 89143; GeneCards: MASP1; OMA:MASP1 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	187,291,980 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	23,339,565 bp
RNA expression pattern
	Top expressed in
	canal of the cervix; ; right lobe of liver; ; apex of heart; ; body of uterus; ; ectocervix; ; stromal cell of endometrium; ; left ventricle; ; ventricular zone; ; muscle layer of sigmoid colon; ; urethra;
	Top expressed in
	decidua; ; left lobe of liver; ; ventricular zone; ; saccule; ; cumulus cell; ; gastrula; ; genital tubercle; ; stroma of bone marrow; ; lumbar subsegment of spinal cord; ; right ventricle;
	More reference expression data
	n/a
Gene ontology
Molecular function	calcium ion binding; peptidase activity; serine-type peptidase activity; protein binding; hydrolase activity; protein homodimerization activity; calcium-dependent protein binding; metal ion binding; serine-type endopeptidase activity;
Cellular component	extracellular region; extracellular space; nucleoplasm; cytosol;
Biological process	complement activation, lectin pathway; receptor-mediated endocytosis; proteolysis; negative regulation of complement activation; immune system process; innate immune response; complement activation;
	Sources:Amigo / QuickGO
Orthologs
	5648
	17174
	ENSG00000127241
	ENSMUSG00000022887
	P48740
	P98064
	NM_001031849; NM_001879; NM_139125
	NM_008555; NM_001359083
	NP_001027019; NP_001870; NP_624302
	NP_032581; NP_001346012
	Wikidata
View/Edit Human	View/Edit Mouse

Mannan-binding lectin serine protease 1 also known as mannose-associated serine protease 1 (MASP-1) is an enzyme that in humans is encoded by the MASP1 gene.

MASP-1 is involved in the lectin pathway of the complement system and is responsible for activating MASP-2 and MASP-3. It is also involved in the process of cleaving complement proteins, C4 and C2, into fragments to form a C3-convertase.