H2AFY

MACROH2A1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1U35, 1ZR3, 1ZR5, 2F8N, 2FXK, 3HQH, 3HSV, 3IID, 3IIF, 3IVB, 5IIT
Identifiers
Aliases	MACROH2A1, H2A.y, H2A/y, H2AF12M, H2AFJ, MACROH2A1.1, mH2A1, macroH2A1.2, H2A histone family member Y, H2AFY, macroH2A.1 histone
External IDs	OMIM: 610054; MGI: 1349392; HomoloGene: 3598; GeneCards: MACROH2A1; OMA:MACROH2A1 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	135,399,914 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	56,284,174 bp
RNA expression pattern
	Top expressed in
	epithelium of nasopharynx; ; monocyte; ; mucosa of pharynx; ; human penis; ; trabecular bone; ; ganglionic eminence; ; buccal mucosa cell; ; amniotic fluid; ; palpebral conjunctiva; ; lower lobe of lung;
	Top expressed in
	saccule; ; otic vesicle; ; Rostral migratory stream; ; otic placode; ; internal carotid artery; ; somite; ; ventricular zone; ; ganglionic eminence; ; mandibular prominence; ; maxillary prominence;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein kinase binding; rDNA binding; protein serine/threonine kinase inhibitor activity; RNA polymerase II transcription regulatory region sequence-specific DNA binding; chromatin binding; double-stranded methylated DNA binding; protein heterodimerization activity; RNA polymerase II core promoter sequence-specific DNA binding; core promoter sequence-specific DNA binding; DNA binding; chromatin DNA binding; enzyme binding; protein binding; nucleosomal DNA binding; promoter-specific chromatin binding;
Cellular component	extracellular exosome; ESC/E(Z) complex; nucleolus; condensed chromosome; chromosome; pericentric heterochromatin; nucleosome; nucleus; nuclear chromosome; sex chromatin; Barr body; chromatin;
Biological process	negative regulation of histone H3-K4 methylation; regulation of ribosomal DNA heterochromatin assembly; dosage compensation; negative regulation of cell cycle G2/M phase transition; epigenetic maintenance of chromatin in transcription-competent conformation; regulation of cell growth; positive regulation of keratinocyte differentiation; negative regulation of protein serine/threonine kinase activity; negative regulation of transcription by RNA polymerase II; nucleosome assembly; negative regulation of protein localization to chromosome, telomeric region; negative regulation of gene expression, epigenetic; negative regulation of histone H3-K27 methylation; regulation of gene expression, epigenetic; positive regulation of maintenance of mitotic sister chromatid cohesion; establishment of protein localization to chromatin; negative regulation of transcription of nucleolar large rRNA by RNA polymerase I; regulation of lipid metabolic process; regulation of response to oxidative stress; negative regulation of response to oxidative stress; positive regulation of response to oxidative stress; chromatin organization;
	Sources:Amigo / QuickGO
Orthologs
	9555
	26914
	ENSG00000113648
	ENSMUSG00000015937
	O75367
	Q9QZQ8
	NM_001040158; NM_004893; NM_138609; NM_138610
	NM_001159513; NM_001159514; NM_001159515; NM_012015
	NP_001035248; NP_004884; NP_613075; NP_613258
	NP_001152985; NP_001152986; NP_001152987; NP_036145
	Wikidata
View/Edit Human	View/Edit Mouse

Core histone macro-H2A.1 is a protein that in humans is encoded by the H2AFY gene.