Low copy number

Low Copy Number (LCN) is a DNA profiling technique developed by the UK Forensic Science Service (FSS) which has been in use since 1999.

In the United Kingdom use of the technique was suspended between 21 December 2007 and 14 January 2008 while the Crown Prosecution Service conducted a review into its use – this suspension has now been lifted.

LCN is an extension of Second Generation Multiplex Plus (SGM Plus) profiling technique. It is a more sensitive technique because it involves a greater amount of copying via polymerase chain reaction (PCR) from a smaller amount of starting material, meaning that a profile can be obtained from only a few cells, which may be as small as a millionth the size of a grain of salt, and amount to just a few cells of skin or sweat left from a fingerprint.

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