Low-density lipoprotein receptor gene family

Low-density lipoprotein receptor domain class A
Structure of a cysteine-rich repeat from the low-density lipoprotein receptor.
Identifiers
SymbolLdl_recept_a
PfamPF00057
InterProIPR002172
SMARTSM00192
PROSITEPS50068
SCOP21ldl / SCOPe / SUPFAM
Membranome5
Available protein structures:
PDB  IPR002172 PF00057 (ECOD; PDBsum)  
AlphaFold
Low-density lipoprotein receptor domain class B
Structure of the LDL receptor extracellular domain at endosomal pH.
Identifiers
SymbolLdl_recept_b
PfamPF00058
Pfam clan6CL0186
InterProIPR000033
SMARTSM00135
PROSITEPS51120
SCOP21lrx / SCOPe / SUPFAM
Available protein structures:
PDB  1ijq​, 1n7d​, 1npe​ IPR000033 PF00058 (ECOD; PDBsum)  
AlphaFold

The low-density lipoprotein receptor gene family codes for a class of structurally related cell surface receptors that fulfill diverse biological functions in different organs, tissues, and cell types. The role that is most commonly associated with this evolutionarily ancient family is cholesterol homeostasis (maintenance of appropriate concentration of cholesterol). In humans, excess cholesterol in the blood is captured by low-density lipoprotein (LDL) and removed by the liver via endocytosis of the LDL receptor. Recent evidence indicates that the members of the LDL receptor gene family are active in the cell signalling pathways between specialized cells in many, if not all, multicellular organisms.

There are seven members of the LDLR family in mammals, namely:

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