Prelamin-A/C

LMNA
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1IFR, 1IVT, 1X8Y, 2XV5, 2YPT, 3GEF, 3V4Q, 3V4W, 3V5B
Identifiers
Aliases	LMNA, CDCD1, CDDC, CMD1A, CMT2B1, EMD2, FPL, FPLD, FPLD2, HGPS, IDC, LDP1, LFP, LGMD1B, LMN1, LMNC, LMNL1, PRO1, lamin A/C, MADA, A-type lamin
External IDs	OMIM: 150330; MGI: 96794; HomoloGene: 41321; GeneCards: LMNA; OMA:LMNA - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	156,140,081 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	88,417,263 bp
RNA expression pattern
	Top expressed in
	nipple; ; gastric mucosa; ; skin of abdomen; ; tendon of biceps brachii; ; gallbladder; ; skin of leg; ; Descending thoracic aorta; ; stromal cell of endometrium; ; Achilles tendon; ; left uterine tube;
	Top expressed in
	ascending aorta; ; aortic valve; ; external carotid artery; ; internal carotid artery; ; endothelial cell of lymphatic vessel; ; lip; ; condyle; ; skin of back; ; skin of external ear; ; lactiferous gland;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	structural molecule activity; protein binding; identical protein binding;
Cellular component	nuclear lamina; cytosol; nuclear speck; lamin filament; perinuclear region of cytoplasm; intermediate filament; nucleus; extracellular matrix; nuclear membrane; nucleoplasm; nuclear envelope;
Biological process	regulation of cell migration; nucleus organization; establishment or maintenance of microtubule cytoskeleton polarity; negative regulation of release of cytochrome c from mitochondria; negative regulation of extrinsic apoptotic signaling pathway; muscle organ development; regulation of protein localization to nucleus; IRE1-mediated unfolded protein response; mitotic nuclear membrane disassembly; protein localization to nucleus; mitotic nuclear membrane reassembly; ventricular cardiac muscle cell development; cellular response to hypoxia; positive regulation of gene expression; negative regulation of mesenchymal cell proliferation; nuclear envelope organization; negative regulation of cell population proliferation; regulation of telomere maintenance; negative regulation of cardiac muscle hypertrophy in response to stress; protein import into nucleus; regulation of protein stability; positive regulation of histone H3-K9 trimethylation;
	Sources:Amigo / QuickGO
Orthologs
	4000
	16905
	ENSG00000160789
	ENSMUSG00000028063
	P02545
	P48678
NM_001257374; NM_001282624; NM_001282625; NM_001282626; NM_005572;
	NM_170707; NM_170708
	NM_001002011; NM_001111102; NM_019390
NP_001244303; NP_001269553; NP_001269554; NP_001269555; NP_005563;
	NP_733821; NP_733822
	NP_001002011; NP_001104572; NP_062263
	Wikidata
View/Edit Human	View/Edit Mouse

Prelamin-A/C, or lamin A/C is a protein that in humans is encoded by the LMNA gene. Lamin A/C belongs to the lamin family of proteins.