LYPLAL1

Available protein structures:
PDB	IPR029058 PF02230 (ECOD; PDBsum)
AlphaFold	IPR029058; PF02230;

	Crystal structure of human LYPLAL1, PDB code 3u0v. Alpha helices are in red, beta strands in gold, catalytic site residues in black.
Identifiers
Symbol	Lysophospholipase-like protein 1
Pfam	PF02230
InterPro	IPR029058
CATH	3u0v
SCOP2	3u0v / SCOPe / SUPFAM
PDB
Available protein structures:
PDB	IPR029058 PF02230 (ECOD; PDBsum)
AlphaFold	IPR029058; PF02230;

Lysophospholipase-like 1 is a protein in humans that is encoded by the LYPLAL1 gene. The protein is a α/β-hydrolase of uncharacterized metabolic function. Genome-wide association studies in humans have linked the gene to fat distribution and waist-to-hip ratio. The protein's enzymatic function is unclear. LYPLAL1 was reported to act as a triglyceride lipase in adipose tissue and another study suggested that the protein may play a role in the depalmitoylation of calcium-activated potassium channels. However, LYPLAL1 does not depalmitoylate the oncogene Ras and a structural and enzymatic study concluded that LYPLAL1 is generally unable to act as a lipase and is instead an esterase that prefers short-chain substrates, such as acetyl groups. Structural comparisons have suggested that LYPLAL1 might be a protein deacetylase, but this has not been experimentally tested.