LSD in Czechoslovakia

Between the 1950s and 1970s, the hallucinogenic drug LSD was extensively studied in the Czechoslovak Socialist Republic, with experiments conducted for both military applications and government-approved psychiatric treatments. Following the expiration of Sandoz’s patents on LSD in 1963, state-owned pharmaceutical company Spofa began manufacturing the compound domestically from 1963 to 1974. In 1965, the authorities approved the commercial production of a local version of LSD under the trademark "Lysergamid," which was also exported to several Western countries. During the years of legality, one of the world's largest clinical LSD programs was conducted in Prague, involving over 700 psychiatric patients and volunteers in more than 6,000 therapeutic sessions.

On October 24, 1968, the possession of LSD was made illegal in the United States, and in 1971, the drug was listed as a Schedule I substance by the United Nations under the Convention on Psychotropic Substances, deeming it to have no therapeutic value. Although the Czechoslovak government did not initially sign the UN convention, it halted LSD production and discontinued clinical use by 1974 due to fears of youth addiction during the period of Normalization. In theory, the drug could still be requested with Health Ministry approval, but in practice, this rarely occurred due to widespread reluctance.