Irofulven

Irofulven
Names
	Preferred IUPAC name (6′R)-6′-Hydroxy-3′-(hydroxymethyl)-2′,4′,6′-trimethylspiro[cyclopropane-1,5′-inden]-7′(6′H)-one
Identifiers
CAS Number	158440-71-2 ;
3D model (JSmol)	Interactive image;
ChEMBL	ChEMBL118218 ;
ChemSpider	130640 ;
KEGG	D04614 ;
PubChem CID	148189;
UNII	6B799IH05A ;
CompTox Dashboard (EPA)	DTXSID50166423 ;
	InChI InChI=1S/C15H18O3/c1-8-6-10-12(11(8)7-16)9(2)15(4-5-15)14(3,18)13(10)17/h6,16,18H,4-5,7H2,1-3H3/t14-/m0/s1 Key: NICJCIQSJJKZAH-AWEZNQCLSA-N ; InChI=1/C15H18O3/c1-8-6-10-12(11(8)7-16)9(2)15(4-5-15)14(3,18)13(10)17/h6,16,18H,4-5,7H2,1-3H3/t14-/m0/s1 Key: NICJCIQSJJKZAH-AWEZNQCLBL;
	SMILES O=C1C/3=C/C(=C(C\3=C(/C2([C@]1(O)C)CC2)C)CO)C;
Properties
Chemical formula	C15H18O3
Molar mass	246.302 g/mol
Density	1.285 g/mL
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). verify (what is ?) Infobox references

Irofulven or 6-hydroxymethylacylfulvene (also known as HMAF and MGI-114) is an experimental cancer drug. It belongs to the family of drugs called alkylating agents.

It inhibits the DNA replication of cultured cells deficient in the nucleotide excision repair pathway.

Irofulven is an analogue of illudin S, a sesquiterpene toxin found in the Jack 'o' Lantern mushroom (Omphalotus illudens). The compound was originally synthesized by Dr. Trevor McMorris and found to have anticancer properties in mice by Dr. Michael J Kelner.