International Celestial Reference System and its realizations
The International Celestial Reference System (ICRS) is the current standard celestial reference system adopted by the International Astronomical Union (IAU). Its origin is at the barycenter of the Solar System, with axes that are intended to "show no global rotation with respect to a set of distant extragalactic objects". The coordinates are basically the declination and right ascension based on the mean celestial equator and mean celestial equinox at the J2000 epoch.
The International Celestial Reference Frame (ICRF) is a realization of the International Celestial Reference System using reference celestial sources observed at radio wavelengths. In the context of the ICRS, a reference frame (RF) is the physical realization of a reference system, i.e., the reference frame is the set of numerical coordinates of the reference sources, derived using the procedures spelled out by the ICRS.
More specifically, the ICRF is an inertial barycentric reference frame whose axes are defined by the measured positions of extragalactic sources (mainly quasars) observed using very-long-baseline interferometry while the Gaia-CRF is an inertial barycentric reference frame defined by optically measured positions of extragalactic sources by the Gaia satellite and whose axes are rotated to conform to the ICRF. Although general relativity implies that there are no true inertial frames around gravitating bodies, these reference frames are important because they do not exhibit any measurable angular rotation since the extragalactic sources used to define the ICRF and the Gaia-CRF are extremely far away. The ICRF and the Gaia-CRF are now the standard reference frames used to define the positions of astronomical objects.