Interleukin 31

IL31
Identifiers
Aliases	IL31, IL-31, interleukin 31
External IDs	OMIM: 609509; MGI: 1923649; HomoloGene: 88541; GeneCards: IL31; OMA:IL31 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	122,174,221 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	123,627,552 bp
RNA expression pattern
	Top expressed in
	gastric mucosa; ; human musculoskeletal system; ; gastrocnemius muscle; ; islet of Langerhans;
	Top expressed in
	spermatid; ; spermatocyte; ; seminiferous tubule; ; zygote; ; placenta; ; islet of Langerhans; ; nucleus of brain; ; telencephalic nucleus; ; hypothalamus; ; basal forebrain;
	More reference expression data
	n/a
Gene ontology
Molecular function	cytokine activity; cytokine receptor binding;
Cellular component	extracellular region; extracellular space;
Biological process	immune system process; regulation of signaling receptor activity; cytokine-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	386653
	76399
	ENSG00000204671
	ENSMUSG00000029437
	Q6EBC2
	Q6EAL8
	NM_001014336
	NM_029594
	NP_001014358
	NP_083870
	Wikidata
View/Edit Human	View/Edit Mouse

Interleukin-31 (IL-31) is a protein that in humans is encoded by the IL31 gene that resides on chromosome 12. IL-31 is an inflammatory cytokine that helps trigger cell-mediated immunity against pathogens. It has also been identified as a major player in a number of chronic inflammatory diseases, including atopic dermatitis.

IL-31 is produced by a variety of cells, namely type 2 helper (T_H2) T-cells. IL-31 sends signals through a receptor complex made of IL-31RA and oncostatin M receptor β (OSMRβ) expressed in immune and epithelial cells. These signals activate three pathways: ERK1/2 MAP kinase, PI3K/AKT, and JAK1/2 signaling pathways.