Interleukin 13

IL13
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1GA3, 1IJZ, 1IK0, 3BPO, 3G6D, 3L5W, 3L5X, 3LB6, 4I77, 4PS4, 5E4E
Identifiers
Aliases	IL13, IL-13, P600, interleukin 13
External IDs	OMIM: 147683; MGI: 96541; HomoloGene: 1649; GeneCards: IL13; OMA:IL13 - orthologs
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	53,525,529 bp
RNA expression pattern
	n/a
	Top expressed in
	embryo; ; secondary oocyte; ; zygote; ; seminiferous tubule; ; thymus; ; spermatocyte; ; hippocampal formation; ; hippocampus proper; ; lip; ; spermatid;
	More reference expression data
Gene ontology
Molecular function	protein binding; cytokine receptor binding; cytokine activity; interleukin-13 receptor binding;
Cellular component	cytoplasm; external side of plasma membrane; extracellular region; extracellular space;
Biological process	negative regulation of endothelial cell apoptotic process; negative regulation of complement-dependent cytotoxicity; negative regulation of transforming growth factor beta production; positive regulation of lung goblet cell differentiation; response to mechanical stimulus; response to nicotine; positive regulation of release of sequestered calcium ion into cytosol; microglial cell activation; negative regulation of NAD(P)H oxidase activity; cellular response to mechanical stimulus; response to lipopolysaccharide; negative regulation of lung ciliated cell differentiation; positive regulation of ion transport; immune response; positive regulation of protein secretion; positive regulation of connective tissue growth factor production; positive regulation of pancreatic stellate cell proliferation; response to ethanol; inflammatory response; regulation of proton transport; positive regulation of smooth muscle cell proliferation; negative regulation of neuron death; positive regulation of immunoglobulin production; positive regulation of B cell proliferation; positive regulation of macrophage activation; positive regulation of mast cell degranulation; cellular response to cytokine stimulus; positive regulation of tyrosine phosphorylation of STAT protein; regulation of signaling receptor activity; cytokine-mediated signaling pathway; positive regulation of gene expression; positive regulation of cold-induced thermogenesis;
	Sources:Amigo / QuickGO
Orthologs
	3596
	16163
	ENSG00000169194
	ENSMUSG00000020383
	P35225
	P20109
	NM_002188
	NM_008355
	NP_002179; NP_001341920; NP_001341921; NP_001341922
	NP_032381
	Wikidata
View/Edit Human	View/Edit Mouse

Interleukin 13 (IL-13) and its relative interleukin-4 are signalling proteins of the adaptive immune systems of vertebrates. They are immunoregulatory cytokines belonging to the type 2 cytokine family, primarily produced by activated T helper 2 (Th2) cells, as well as innate lymphoid cells type 2 (ILC2s), natural killer T cell, mast cells, basophils, eosinophils and nuocytesduring type 2 immune responses. Type 2 immune responses are essential for defense against large extracellular parasites like helminths, by promoting B-cell maturation, immunoglobulin E (IgE) class switching, eosinophil recruitment, mucus production, and alternative (M2) macrophage polarization that suppresses excessive inflammation and supports tissue repair. Interleukin-13 is a central regulator in IgE synthesis, goblet cell hyperplasia, mucus hypersecretion, airway hyperresponsiveness, fibrosis and chitinase up-regulation. It is a mediator of allergic inflammation and different diseases including asthma, and atopic dermatitis.