IL-2 receptor

interleukin 2 receptor, alpha chain
Structure of IL-2 (helical protein) with IL2RA (sheet-rich protein). PDB rendering based on 1z92.
Identifiers
SymbolIL2RA
Alt. symbolsIL2R CD25
NCBI gene3559
HGNC6008
OMIM147730
RefSeqNM_000417
UniProtP01589
Other data
LocusChr. 10 p15.1
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interleukin 2 receptor, beta chain
Structure of IL2 with one chain of IL2RA, two chains of IL2RB, two chains of IL2RG. PDB rendering based on 2b5i.
Identifiers
SymbolIL2RB
Alt. symbolsCD122
NCBI gene3560
HGNC6009
OMIM146710
RefSeqNM_000878
UniProtP14784
Other data
LocusChr. 22 q13
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interleukin 2 receptor, gamma chain (severe combined immunodeficiency)
Crystallographic structure of IL-2 (center alpha helices) complexed with the common gamma chain (IL2RG; 10 O'Clock to 1 O'Clock), IL2RA (4 O'Clock), and IL2RB (7 O'Clock to 9 O'Clock). Each protein is individually rainbow colored (N-terminus = blue, C-terminus = red).
Identifiers
SymbolIL2RG
Alt. symbolsSCIDX1, IMD4, CD132
NCBI gene3561
HGNC6010
OMIM308380
RefSeqNM_000206
UniProtP31785
Other data
LocusChr. X q13
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StructuresSwiss-model
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The interleukin-2 receptor (IL-2R) is a heterotrimeric protein expressed on the surface of certain immune cells, such as lymphocytes, that binds and responds to a cytokine called IL-2.

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