Integrase

Integrase Zinc binding domain
solution structure of the N-terminal Zn binding domain of HIV-1 integrase (e form), NMR, 38 structures
Identifiers
SymbolIntegrase_Zn
PfamPF02022
InterProIPR003308
SCOP21wjb / SCOPe / SUPFAM
Available protein structures:
PDB  IPR003308 PF02022 (ECOD; PDBsum)  
AlphaFold
Integrase core domain
Crystal structure of the RSV two-domain integrase.
Identifiers
Symbolrve
PfamPF00665
Pfam clanCL0219
InterProIPR001584
SCOP22itg / SCOPe / SUPFAM
Available protein structures:
PDB  IPR001584 PF00665 (ECOD; PDBsum)  
AlphaFold
Integrase DNA binding domain
Crystal structure of the RSV two-domain integrase.
Identifiers
SymbolIN_DBD_C
PfamPF00552
InterProIPR001037
SCOP21ihw / SCOPe / SUPFAM
Available protein structures:
PDB  IPR001037 PF00552 (ECOD; PDBsum)  
AlphaFold

Retroviral integrase (IN) is an enzyme produced by a retrovirus (such as HIV) that integrates (forms covalent links between) its genetic information into that of the host cell it infects. Retroviral INs are not to be confused with phage integrases (recombinases) used in biotechnology, such as λ phage integrase, as discussed in site-specific recombination.

The macromolecular complex of an IN macromolecule bound to the ends of the viral DNA ends has been referred to as the intasome; IN is a key component in this and the retroviral pre-integration complex.

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