Indalpine

Indalpine
Clinical data
Trade namesUpstène
Other namesLM-5008
Identifiers
  • 3-(2-piperidin-4-ylethyl)-1H-indole
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.058.569
Chemical and physical data
FormulaC15H20N2
Molar mass228.339 g·mol−1
3D model (JSmol)
  • c2(c1ccccc1[nH]c2)CCC3CCNCC3
  • InChI=1S/C15H20N2/c1-2-4-15-14(3-1)13(11-17-15)6-5-12-7-9-16-10-8-12/h1-4,11-12,16-17H,5-10H2 Y
  • Key:SADQVAVFGNTEOD-UHFFFAOYSA-N Y

Indalpine, sold under the brand name Upstène, is a selective serotonin reuptake inhibitor (SSRI) that was briefly marketed as an antidepressant for treatment of depression. It was marketed in France and a few other European countries.

Indalpine is a selective serotonin reuptake inhibitor (SSRI) and antihistamine.

Indalpine was invented by 1977 and was introduced for medical use in France in 1983. Two years later, in 1985, it was withdrawn from the market due to toxicity. Indalpine has sometimes been said to be the first SSRI. However, it was preceded by the SSRI zimelidine (Zelmid), which was invented in 1969 and was introduced to the market in 1981 (then similarly withdrawn due to toxicity in 1983).