Inclacumab

Inclacumab
Monoclonal antibody
TypeWhole antibody
SourceHuman
Targetselectin P
Clinical data
Other namesLC1004-002
ATC code
  • none
Identifiers
CAS Number
ChemSpider
  • none
UNII
KEGG
Chemical and physical data
FormulaC6452H9930N1730O2024S42
Molar mass145465.02 g·mol−1

Inclacumab (also known as LC-1004-002, RO4905417, and PF-07940370) is an investigational monoclonal antibody originally developed by Roche for cardiovascular disease and later acquired by Global Blood Therapeutics (GBT), which was subsequently acquired by Pfizer in 2022 for $5.4 billion. It is a fully human monoclonal antibody against P-selectin being developed primarily for the treatment of sickle cell disease with vaso-occlusive crises.

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