Involucrin

Available protein structures:
PDB	IPR019571 PF10583 (ECOD; PDBsum)
AlphaFold	IPR019571; PF10583;

Involucrin of squamous epithelia N-terminus
Involucrin of squamous epithelia N-terminus
Identifiers
Symbol	Involucrin_N
Pfam	PF10583
InterPro	IPR019571
PDB
Available protein structures:
PDB	IPR019571 PF10583 (ECOD; PDBsum)
AlphaFold	IPR019571; PF10583;

IVL
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1EU0
Identifiers
Aliases	IVL, involucrin
External IDs	OMIM: 147360; MGI: 96626; HomoloGene: 136793; GeneCards: IVL; OMA:IVL - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	152,911,886 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	92,481,042 bp
RNA expression pattern
	Top expressed in
	gingival epithelium; ; oral cavity; ; skin of abdomen; ; skin of leg; ; vulva; ; skin of thigh; ; mucosa of pharynx; ; testicle; ; amniotic fluid; ; human penis;
	Top expressed in
	transitional epithelium of urinary bladder; ; skin of external ear; ; skin of back; ; umbilical cord; ; lip; ; skin of abdomen; ; epidermis; ; granular layer of epidermis; ; hair follicle; ; condyle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein-macromolecule adaptor activity; protein binding; structural molecule activity;
Cellular component	cytoplasm; extracellular exosome; cornified envelope; centrosome; cytosol; nuclear body;
Biological process	response to UV-B; peptide cross-linking; keratinization; isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine; keratinocyte differentiation; cornification;
	Sources:Amigo / QuickGO
Orthologs
	3713
	16447
	ENSG00000163207
	ENSMUSG00000049128
	P07476
	P48997
	NM_005547
	NM_008412
	NP_005538
	NP_032438
	Wikidata
View/Edit Human	View/Edit Mouse

Involucrin repeat

Identifiers

Symbol

Involucrin

1eu0 / SCOPe / SUPFAM

Available protein structures:
PDB	IPR000354 PF00904 (ECOD; PDBsum)
AlphaFold	IPR000354 PF00904

Involucrin repeat

Identifiers

Symbol

Involucrin2

Available protein structures:
PDB	IPR009733 PF06994 (ECOD; PDBsum)
AlphaFold	IPR009733 PF06994

Involucrin is a protein component of human skin and in humans is encoded by the IVL gene. In binding the protein loricrin, involucrin contributes to the formation of a cell envelope that protects corneocytes in the skin.