ITPR1

ITPR1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1N4K, 1XZZ
Identifiers
Aliases	ITPR1, ACV, CLA4, INSP3R1, IP3R, IP3R1, PPP1R94, SCA15, SCA16, SCA29, inositol 1,4,5-trisphosphate receptor type 1
External IDs	OMIM: 147265; MGI: 96623; HomoloGene: 1673; GeneCards: ITPR1; OMA:ITPR1 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	4,847,506 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	108,528,070 bp
RNA expression pattern
	Top expressed in
	tail of epididymis; ; Brodmann area 23; ; primary visual cortex; ; right coronary artery; ; popliteal artery; ; tibial arteries; ; seminal vesicula; ; right hemisphere of cerebellum; ; orbitofrontal cortex; ; left coronary artery;
	Top expressed in
	cerebellar vermis; ; lobe of cerebellum; ; olfactory tubercle; ; vestibular membrane of cochlear duct; ; primary motor cortex; ; Epithelium of choroid plexus; ; cingulate gyrus; ; Region I of hippocampus proper; ; superior frontal gyrus; ; choroid plexus of fourth ventricle;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	calcium channel inhibitor activity; calcium channel activity; inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; calcium ion transmembrane transporter activity; ion channel activity; protein binding; phosphatidylinositol binding; calcium-release channel activity; calcium ion binding; inositol 1,4,5 trisphosphate binding; inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels;
Cellular component	cytoplasm; integral component of membrane; platelet dense tubular network; endoplasmic reticulum membrane; membrane; postsynaptic density; nuclear envelope; calcineurin complex; sarcoplasmic reticulum; nuclear inner membrane; platelet dense granule membrane; nucleolus; platelet dense tubular network membrane; plasma membrane; transport vesicle membrane; cytoplasmic vesicle; perinuclear region of cytoplasm; endoplasmic reticulum; cytoplasmic vesicle membrane; secretory granule membrane; protein-containing complex; Schaffer collateral - CA1 synapse;
Biological process	release of sequestered calcium ion into cytosol; regulation of cardiac conduction; response to hypoxia; voluntary musculoskeletal movement; regulation of insulin secretion; epithelial fluid transport; ion transport; post-embryonic development; endoplasmic reticulum calcium ion homeostasis; platelet activation; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; regulation of autophagy; transmembrane transport; calcium ion transmembrane transport; negative regulation of calcium-mediated signaling; inositol phosphate-mediated signaling; calcium ion transport; apoptotic process; signal transduction; regulation of molecular function; transport; regulation of postsynaptic cytosolic calcium ion concentration;
	Sources:Amigo / QuickGO
Orthologs
	3708
	16438
	ENSG00000150995
	ENSMUSG00000030102
	Q14643
	P11881
	NM_001099952; NM_001168272; NM_002222; NM_001378452
	NM_010585
	NP_001093422; NP_001161744; NP_002213
	NP_034715
	Wikidata
View/Edit Human	View/Edit Mouse

Inositol 1,4,5-trisphosphate receptor type 1 is a protein that in humans is encoded by the ITPR1 gene.