ISG20

ISG20
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1WLJ
Identifiers
Aliases	ISG20, CD25, HEM45, interferon stimulated exonuclease gene 20kDa, interferon stimulated exonuclease gene 20
External IDs	OMIM: 604533; MGI: 1928895; HomoloGene: 31081; GeneCards: ISG20; OMA:ISG20 - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	88,656,483 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	78,570,144 bp
RNA expression pattern
	Top expressed in
	spleen; ; blood; ; granulocyte; ; lymph node; ; cartilage tissue; ; appendix; ; duodenum; ; jejunal mucosa; ; epithelium of nasopharynx; ; right lung;
	Top expressed in
	tibiofemoral joint; ; blood; ; spermatid; ; islet of Langerhans; ; spleen; ; decidua; ; right lung lobe; ; gastrula; ; thymus; ; fetal liver hematopoietic progenitor cell;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	3'-5'-exoribonuclease activity; single-stranded DNA 3'-5' exodeoxyribonuclease activity; exoribonuclease II activity; metal ion binding; U3 snoRNA binding; U2 snRNA binding; RNA binding; nucleic acid binding; U1 snRNA binding; nuclease activity; exonuclease activity; hydrolase activity;
Cellular component	cytoplasm; Cajal body; PML body; nucleoplasm; nucleolus; nucleus;
Biological process	immune system process; response to virus; RNA catabolic process; negative regulation of viral genome replication; DNA catabolic process, exonucleolytic; defense response to virus; type I interferon signaling pathway; rRNA processing; innate immune response; cell population proliferation; RNA phosphodiester bond hydrolysis, exonucleolytic;
	Sources:Amigo / QuickGO
Orthologs
	3669
	57444
	ENSG00000172183
	ENSMUSG00000039236
	Q96AZ6
	Q9JL16
NM_001303233; NM_001303234; NM_001303235; NM_001303236; NM_001303237;
	NM_002201
	NM_001113527; NM_001291220; NM_001291221; NM_020583
NP_001290162; NP_001290163; NP_001290164; NP_001290165; NP_001290166;
	NP_002192
	NP_001106999; NP_001278149; NP_001278150; NP_065608
	Wikidata
View/Edit Human	View/Edit Mouse

Interferon-stimulated gene 20 kDa protein is a protein that in humans is encoded by the ISG20 gene. It belongs to the ISG family of proteins, which are typically stimulated by type I interferon as a response to viral infection.