Insulin-degrading enzyme

IDE
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2G47, 2G48, 2G49, 2G54, 2G56, 2JBU, 2JG4, 2WBY, 2WC0, 2WK3, 2YPU, 3CWW, 3E4A, 3E4Z, 3E50, 3H44, 3HGZ, 3N56, 3N57, 3OFI, 3QZ2, 4DTT, 4DWK, 4GS8, 4GSC, 4GSF, 4IFH, 4IOF, 4LTE, 4M1C, 4Q5Z, 4QIA, 4RAL, 4PES, 4PF7, 4PF9, 4PFC, 4NXO, 4RE9, 5CJO
Identifiers
Aliases	IDE, INSULYSIN, insulin degrading enzyme
External IDs	OMIM: 146680; MGI: 96412; HomoloGene: 3645; GeneCards: IDE; OMA:IDE - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	92,574,096 bp
RNA expression pattern
	Top expressed in
	skin of thigh; ; secondary oocyte; ; glutes; ; Skeletal muscle tissue of rectus abdominis; ; human penis; ; triceps brachii muscle; ; right ventricle; ; biceps brachii; ; Skeletal muscle tissue of biceps brachii; ; vulva;
	n/a
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; protein homodimerization activity; virus receptor activity; peptide binding; zinc ion binding; amyloid-beta binding; insulin binding; metal ion binding; protein binding; peptide hormone binding; peptidase activity; ATPase activity; beta-endorphin binding; catalytic activity; ubiquitin binding; metalloendopeptidase activity; signaling receptor binding; hydrolase activity; ATP binding; metallopeptidase activity; ubiquitin-dependent protein binding; endopeptidase activity;
Cellular component	cytoplasm; cytosol; membrane; plasma membrane; peroxisome; extracellular region; cell surface; cytosolic proteasome complex; mitochondrion; nucleus; extracellular space; peroxisomal matrix; external side of plasma membrane; basolateral plasma membrane; extracellular exosome;
Biological process	negative regulation of proteolysis; insulin receptor signaling pathway; insulin metabolic process; bradykinin catabolic process; determination of adult lifespan; protein heterooligomerization; hormone catabolic process; amyloid-beta metabolic process; proteolysis; positive regulation of protein oligomerization; viral entry into host cell; metabolism; proteolysis involved in cellular protein catabolic process; ubiquitin recycling; viral process; protein homooligomerization; protein homotetramerization; insulin catabolic process; protein targeting to peroxisome; protein catabolic process; positive regulation of protein catabolic process; amyloid-beta clearance; amyloid-beta clearance by cellular catabolic process; regulation of aerobic respiration; antigen processing and presentation of endogenous peptide antigen via MHC class I; peptide catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	3416
	15925
	ENSG00000119912
	ENSMUSG00000056999
	P14735
	Q8CGB9
NM_001165946; NM_004969; NM_001322793; NM_001322794; NM_001322795;
	NM_001322796; NM_001322797
	NM_031156
NP_001159418; NP_001309722; NP_001309723; NP_001309724; NP_001309725;
	NP_001309726; NP_004960
	NP_112419
	Wikidata
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Insulin-degrading enzyme (IDE) (also known as insulinase, insulin protease, or insulysin) is a large zinc-binding protease of the M16 metalloprotease family of enzymes. It is known to cleave multiple short polypeptides that vary considerably in sequence, including insulin. Other members of this family include the mitochondrial processing peptidase and presequence protease. Insulin-degrading enzyme is coded for in the human by the IDE gene.