Herpes simplex virus protein vmw65
| Alpha trans-inducing protein (Alpha-TIF) | |||||||
|---|---|---|---|---|---|---|---|
Structure of the conserved core of the herpes simplex virus transcriptional regulatory protein VP16. | |||||||
| Identifiers | |||||||
| Symbol | Alpha_TIF | ||||||
| Pfam | PF02232 | ||||||
| InterPro | IPR003174 | ||||||
| SMART | SM00814 | ||||||
| SCOP2 | 16vp / SCOPe / SUPFAM | ||||||
| |||||||
Vmw65, also known as VP16 or α-TIF (Trans Inducing Factor) is a trans-acting protein that forms a complex with the host transcription factors Oct-1 and HCF to induce immediate early gene transcription in the herpes simplex viruses.
VP16 is a strong transactivator and is often used in Y2H systems as the activation domain of the system.