Helix-turn-helix

Helix-turn-helix
Identifiers
SymbolHTH
Pfam clanCL0123
ECOD101.1

The helix-turn-helix (HTH) is a major structural motif in proteins that functions as a DNA-binding domain (DBD). Each monomer incorporates two α helices, joined by a short strand of amino acids, that bind to the major groove of DNA. The HTH motif occurs in many proteins that regulate gene expression. It should not be confused with the helix–loop–helix motif.

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