Haldane's dilemma

Haldane's dilemma is a limit on the speed of beneficial evolution, calculated by J. B. S. Haldane in 1957. Motoo Kimura's landmark paper on neutral theory in 1968 built on Haldane's work to suggest that most molecular evolution across species is neutral, framing this is as a resolution to the dilemma. However, adaptive evolution might explain a significant fraction of substitutions in protein coding sequence,. Other solutions have since been proposed.

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