Cholest-5-ene-3beta,7alpha-diol 3beta-dehydrogenase
| cholest-5-ene-3β,7α-diol 3β-dehydrogenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.1.1.181 | ||||||||
| CAS no. | 56626-16-5 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
| hydroxy-Δ-5-steroid dehydrogenase, 3β- and steroid Δ-isomerase 7 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | HSD3B7 | ||||||
| NCBI gene | 80270 | ||||||
| HGNC | 18324 | ||||||
| OMIM | 607764 | ||||||
| RefSeq | NM_025193 | ||||||
| UniProt | Q9H2F3 | ||||||
| Other data | |||||||
| EC number | 1.1.1.181 | ||||||
| Locus | Chr. 16 p11.2 | ||||||
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In enzymology, a cholest-5-ene-3β,7α-diol 3β-dehydrogenase (EC 1.1.1.181) is an enzyme that catalyzes several chemical reactions of steroids.
The primary reaction is to convert 7α-hydroxycholesterol to 7α-hydroxycholest-4-en-3-one:
The two substrates are 7α-hydroxycholesterol and oxidised nicotinamide adenine dinucleotide (NAD+). The products are 7α-hydroxycholest-4-en-3-one, reduced NADH, and a proton.
The systematic name of this enzyme class is cholest-5-ene-3β,7α-diol:NAD+ 3-oxidoreductase. This enzyme is also called 3β-hydroxy-Δ5-C27-steroid oxidoreductase. The human version of this enzyme is known as hydroxy-Δ-5-steroid dehydrogenase, 3 β- and steroid delta-isomerase 7 or HSD3B7 which is encoded by the HSD3B7 gene.