HMOX1

HMOX1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1N3U, 1N45, 1NI6, 1OYK, 1OYL, 1OZE, 1OZL, 1OZR, 1OZW, 1S13, 1S8C, 1T5P, 1TWN, 1TWR, 1XJZ, 1XK0, 1XK1, 1XK2, 1XK3, 3CZY, 3HOK, 3K4F, 3TGM, 4WD4, 5BTQ
Identifiers
Aliases	HMOX1, HMOX1D, HO-1, HSP32, bK286B10, heme oxygenase 1
External IDs	OMIM: 141250; MGI: 96163; HomoloGene: 31075; GeneCards: HMOX1; OMA:HMOX1 - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	35,394,214 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	75,827,217 bp
RNA expression pattern
	Top expressed in
	cartilage tissue; ; spleen; ; monocyte; ; granulocyte; ; islet of Langerhans; ; left ovary; ; mucosa of transverse colon; ; skin of leg; ; gallbladder; ; right ovary;
	Top expressed in
	stroma of bone marrow; ; spleen; ; tibiofemoral joint; ; lens; ; granulocyte; ; lip; ; esophagus; ; placenta; ; calvaria; ; yolk sac;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	phospholipase D activity; protein homodimerization activity; heme oxygenase (decyclizing) activity; metal ion binding; signal transducer activity; heme binding; protein binding; enzyme binding; oxidoreductase activity;
Cellular component	cytosol; endoplasmic reticulum membrane; membrane; intracellular membrane-bounded organelle; nucleolus; endoplasmic reticulum; caveola; perinuclear region of cytoplasm; nucleus; extracellular space;
Biological process	negative regulation of neuron apoptotic process; apoptotic process; cellular iron ion homeostasis; negative regulation of smooth muscle cell proliferation; cellular response to heat; intracellular signal transduction; negative regulation of mast cell cytokine production; response to hypoxia; excretion; low-density lipoprotein particle clearance; regulation of transcription from RNA polymerase II promoter in response to oxidative stress; small GTPase mediated signal transduction; negative regulation of DNA binding; response to nicotine; iron ion homeostasis; cell death; heme oxidation; negative regulation of mast cell degranulation; cellular response to cadmium ion; regulation of angiogenesis; negative regulation of muscle cell apoptotic process; response to oxidative stress; negative regulation of DNA-binding transcription factor activity; cellular response to nutrient; positive regulation of angiogenesis; response to estrogen; wound healing involved in inflammatory response; regulation of blood pressure; heme catabolic process; erythrocyte homeostasis; regulation of DNA-binding transcription factor activity; cellular response to arsenic-containing substance; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; angiogenesis; intrinsic apoptotic signaling pathway in response to DNA damage; endothelial cell proliferation; positive regulation of I-kappaB kinase/NF-kappaB signaling; smooth muscle hyperplasia; protein homooligomerization; negative regulation of leukocyte migration; cellular response to hypoxia; response to hydrogen peroxide; negative regulation of cell population proliferation; heme metabolic process; positive regulation of smooth muscle cell proliferation; regulation of transcription from RNA polymerase II promoter in response to iron; positive regulation of apoptotic process; cellular response to cisplatin; positive regulation of macroautophagy; negative regulation of vascular associated smooth muscle cell proliferation; negative regulation of epithelial cell apoptotic process; liver regeneration; negative regulation of macroautophagy;
	Sources:Amigo / QuickGO
Orthologs
	3162
	15368
	ENSG00000100292
	ENSMUSG00000005413
	P09601
	P14901
	NM_002133
	NM_010442
	NP_002124
	NP_034572
	Wikidata
View/Edit Human	View/Edit Mouse

HMOX1 (heme oxygenase 1 gene) is a human gene that encodes for the enzyme heme oxygenase 1 (EC 1.14.99.3). Heme oxygenase (abbreviated HMOX or HO) mediates the first step of heme catabolism, it cleaves heme to form biliverdin.

The HMOX gene is located on the long (q) arm of chromosome 22 at position 12.3, from base pair 34,101,636 to base pair 34,114,748.