HMG-box

Available protein structures:
PDB	1aab, 1cg7, 1ckt, 1e7j, 1gt0, 1hme, 1hmf, 1hry, 1hrz, 1hsm, 1hsn, 1i11, 1j3x, 1j46, 1j47, 1j5n, 1k99, 1lwm, 1nhm, 1nhn, 1o4x, 1qrv, 1s9m, 1sx9, 1v64, 1wgf, 1wxl, 2crj, 2cs1, 2lef IPR009071 PF00505 (ECOD; PDBsum)
AlphaFold	IPR009071; PF00505;

HMG (high-mobility group) box
HMG (high-mobility group) box
	NMR structure of the HMG-box domain of the LEF1 protein (rainbow colored, N-terminus = blue, C-terminus = red) complexed with DNA (brown) based on the PDB: 2LEF coordinates.
Identifiers
Symbol	PF00505
Pfam	PF00505
Pfam clan	CL0114
ECOD	190.1.1
InterPro	IPR009071
SCOP2	1hsm / SCOPe / SUPFAM
PDB
Available protein structures:
PDB	1aab, 1cg7, 1ckt, 1e7j, 1gt0, 1hme, 1hmf, 1hry, 1hrz, 1hsm, 1hsn, 1i11, 1j3x, 1j46, 1j47, 1j5n, 1k99, 1lwm, 1nhm, 1nhn, 1o4x, 1qrv, 1s9m, 1sx9, 1v64, 1wgf, 1wxl, 2crj, 2cs1, 2lef IPR009071 PF00505 (ECOD; PDBsum)
AlphaFold	IPR009071; PF00505;

In molecular biology, the HMG-box (high-mobility group box) is a protein domain which is involved in DNA binding. The domain is composed of approximately 75 amino acid residues that collectively mediate the DNA-binding of chromatin-associated high-mobility group proteins. HMG-boxes are present in many transcription factors and chromatin-remodeling complexes, where they can mediate non-sequence or sequence-specific DNA binding.