Guanylate-binding protein

Guanylate-binding protein, N-terminal domain
structure of human guanylate binding protein-1 in nucleotide free form
Identifiers
SymbolGBP
PfamPF02263
Pfam clanCL0023
InterProIPR015894
SCOP21dg3 / SCOPe / SUPFAM
Available protein structures:
PDB  IPR015894 PF02263 (ECOD; PDBsum)  
AlphaFold
Guanylate-binding protein, C-terminal domain
Structure of human guanylate binding protein-1 in nucleotide free form
Identifiers
SymbolGBP_C
PfamPF02841
InterProIPR003191
SCOP21dg3 / SCOPe / SUPFAM
Available protein structures:
PDB  IPR003191 PF02841 (ECOD; PDBsum)  
AlphaFold

In molecular biology, the guanylate-binding proteins family is a family of GTPases that is induced by interferon (IFN)-gamma. GTPases induced by IFN-gamma (Interferon-inducible GTPase) are key to the protective immunity against microbial and viral pathogens. These GTPases are classified into three groups: the small 47-KD immunity-related GTPases (IRGs), the Mx proteins (MX1, MX2), and the large 65- to 67-kd GTPases. Guanylate-binding proteins (GBP) fall into the last class.

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