GrpE

GrpE Protein
Crystal structure of GrpE homodimer interacting with ATPase binding site of DnaK, resolved at 2.8 angstrom.
Identifiers
SymbolGrpE
PfamPF01025
InterProIPR000740
PROSITEPS01071
SCOP21dkg / SCOPe / SUPFAM
CDDcd00446
Available protein structures:
PDB  IPR000740 PF01025 (ECOD; PDBsum)  
AlphaFold

GrpE (Gro-P like protein E) is a bacterial nucleotide exchange factor that is important for regulation of protein folding machinery, as well as the heat shock response. It is a heat-inducible protein and during stress it prevents unfolded proteins from accumulating in the cytoplasm. Accumulation of unfolded proteins in the cytoplasm can lead to cell death.

This article is issued from Wikipedia. The text is available under Creative Commons Attribution-Share Alike 4.0 unless otherwise noted. Additional terms may apply for the media files.