Growth factor-like domain

Available protein structures:
PDB	1mwp, 1owt, 2fjz, 2fk1, 2fk2, 2fk3, 2fkl, 2fma IPR008154 PF02177 (ECOD; PDBsum)
AlphaFold	IPR008154; PF02177;

Amyloid precursor N-terminal
Amyloid precursor N-terminal
	The GFLD region of amyloid precursor protein
Identifiers
Symbol	APP_CU_bd
Pfam	PF02177
InterPro	IPR008154
SMART	SM00006
SCOP2	1mwp / SCOPe / SUPFAM
PDB
Available protein structures:
PDB	1mwp, 1owt, 2fjz, 2fk1, 2fk2, 2fk3, 2fkl, 2fma IPR008154 PF02177 (ECOD; PDBsum)
AlphaFold	IPR008154; PF02177;

A growth factor-like domain (GFLD) is a protein domain structurally related to epidermal growth factor, which has a high binding affinity for the epidermal growth factor receptor. As structural domains within larger proteins, GFLD regions commonly bind calcium ions. A subtype present in the N-terminal region of the amyloid precursor protein is a member of the heparin-binding class of GFLDs and may itself have growth factor function, particularly in promoting neuronal development.