Grey's Anatomy season 22

*Grey's Anatomy*
Grey's Anatomy
Season 22
	Promotional poster
Showrunner	Meg Marinis
Starring	Ellen Pompeo; Chandra Wilson; James Pickens, Jr.; Kevin McKidd; Caterina Scorsone; Camilla Luddington; Jason George; Kim Raver; Chris Carmack; Anthony Hill; Alexis Floyd; Harry Shum Jr.; Adelaide Kane; Niko Terho; Trevor Jackson;
No. of episodes	13
Release
Original network	ABC
Original release	October 9, 2025 –; present
Season chronology

The twenty-second season of the American medical drama television series Grey's Anatomy was announced on April 3, 2025, and premiered in the United States on the American Broadcasting Company (ABC) on October 9, 2025.

This is the first season not to feature Jake Borelli and Midori Francis as series regulars since the sixteenth and nineteenth seasons, respectively.