Gram domain containing 1a

GRAMD1A
Identifiers
Aliases	GRAMD1A, KIAA1533, GRAM domain containing 1A, Aster-A
External IDs	MGI: 105490; HomoloGene: 10843; GeneCards: GRAMD1A; OMA:GRAMD1A - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	35,026,471 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	30,855,321 bp
RNA expression pattern
	Top expressed in
	body of pancreas; ; upper lobe of left lung; ; right uterine tube; ; left uterine tube; ; canal of the cervix; ; left ovary; ; right ovary; ; gastric mucosa; ; appendix; ; right lung;
	Top expressed in
	granulocyte; ; thymus; ; lymph node; ; superior frontal gyrus; ; ganglionic eminence; ; muscle of thigh; ; visual cortex; ; primary visual cortex; ; ventricular zone; ; interventricular septum;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; cholesterol binding; cholesterol transfer activity; lipid binding;
Cellular component	membrane; integral component of membrane; intrinsic component of endoplasmic reticulum membrane; extrinsic component of cytoplasmic side of plasma membrane; organelle membrane contact site; endoplasmic reticulum; endoplasmic reticulum membrane; plasma membrane; endoplasmic reticulum-plasma membrane contact site;
Biological process	cholesterol transport; cellular response to cholesterol; intermembrane sterol transfer; lipid transport;
	Sources:Amigo / QuickGO
Orthologs
	57655
	52857
	ENSG00000089351
	ENSMUSG00000001248
	Q96CP6
	Q8VEF1
	NM_001136199; NM_020895; NM_001320034; NM_001320035; NM_001320036
	NM_027898; NM_001360351
	NP_001129671; NP_001306963; NP_001306964; NP_001306965; NP_065946
	NP_082174; NP_001347280
	Wikidata
View/Edit Human	View/Edit Mouse

GRAM domain containing 1A also known as Aster-A is a protein that is encoded by the GRAMD1A gene. It contains a transmembrane region, a GRAM domain and a VASt domain that can bind cholesterol. GRAMD1A has four paralogs: GRAMD1B and GRAMD1C and two without VASt domains, GRAMD2A and GRAMD2B. These proteins are mammalian representatives of the yeast lipid transfer proteins anchored at a membrane contact site (LAM) family.

The protein is expressed ubiquitously with higher levels in the central nervous system.