Glutamate formimidoyltransferase

Formiminotransferase domain, N-terminal subdomain
Formiminotransferase domain of formiminotransferase-cyclodeaminase, homodimer, Sus scrofa
Identifiers
SymbolFTCD_N
PfamPF07837
InterProIPR012886
SCOP21qd1 / SCOPe / SUPFAM
Available protein structures:
PDB  IPR012886 PF07837 (ECOD; PDBsum)  
AlphaFold
Formiminotransferase domain
the crystal structure of the formiminotransferase domain of formiminotransferase-cyclodeaminase.
Identifiers
SymbolFTCD
PfamPF02971
InterProIPR013802
SCOP21qd1 / SCOPe / SUPFAM
Available protein structures:
PDB  IPR013802 PF02971 (ECOD; PDBsum)  
AlphaFold

Glutamate formimidoyltransferase is a methyltransferase enzyme which uses tetrahydrofolate as part of histidine catabolism. It catalyses two reactions. In the first, N-formimidoyl-L-glutamate (from histidine) transfers its formimidoyl group to tetrahydrofolate.

formiminoglutamic acid
+
 
THFA
 
 
 
 
 
 
L-glutamic acid
+
 
5-formiminotetrahydrofolate

Alternatively, the enzyme can catalyse the transfer of a formyl group from N-formyl-L-glutamic acid.

formylglutamic acid
+
 
THFA
 
 
 
 
 
 
L-glutamic acid
+
 
folinic acid

It is classified under EC 2.1.2.5 and in mammals is found as part of a bifunctional enzyme that also has formimidoyltetrahydrofolate cyclodeaminase activity.

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