Glucagon receptor

GCGR
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3CZF, 4ERS, 4L6R, 2A83, 4LF3, 5EE7
Identifiers
Aliases	GCGR, GGR, GL-R, glucagon receptor, MVAH
External IDs	OMIM: 138033; MGI: 99572; HomoloGene: 131; GeneCards: GCGR; OMA:GCGR - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	81,814,008 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	120,429,812 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; tibial nerve; ; sural nerve; ; human kidney; ; gonad; ; islet of Langerhans; ; skin of abdomen; ; body of pancreas; ; skin of leg; ; muscle layer of sigmoid colon;
	Top expressed in
	lobe of liver; ; left lobe of liver; ; right kidney; ; medullary collecting duct; ; islet of Langerhans; ; footplate; ; human kidney; ; renal cortex; ; yolk sac; ; proximal tubule;
	More reference expression data
	n/a
Gene ontology
Molecular function	G protein-coupled receptor activity; guanyl-nucleotide exchange factor activity; signal transducer activity; peptide hormone binding; glucagon receptor activity; transmembrane signaling receptor activity; G protein-coupled peptide receptor activity;
Cellular component	integral component of membrane; endosome; membrane; plasma membrane; integral component of plasma membrane;
Biological process	glucose homeostasis; response to nutrient; adenylate cyclase-modulating G protein-coupled receptor signaling pathway; cellular response to glucagon stimulus; generation of precursor metabolites and energy; regulation of glycogen metabolic process; regulation of blood pressure; cell surface receptor signaling pathway; hormone-mediated signaling pathway; response to starvation; signal transduction; exocytosis; adenylate cyclase-activating G protein-coupled receptor signaling pathway; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	2642
	14527
	ENSG00000215644; ENSG00000288269
	ENSMUSG00000025127
	P47871
	Q61606
	NM_000160
	NM_008101
	NP_000151
	NP_032127
	Wikidata
View/Edit Human	View/Edit Mouse

The glucagon receptor is a 62 kDa protein that is activated by glucagon and is a member of the class B G-protein coupled family of receptors (secretin receptor family), coupled to G_s and to a lesser extent G_q, & potentially G_i. Stimulation of the G_s receptor results in the activation of adenylate cyclase, which in turn leads to increased levels of the secondary messengers intracellular cAMP and calcium. In humans, the glucagon receptor is encoded by the GCGR gene.

Glucagon receptors are mainly expressed in liver and in kidney with lesser amounts found in heart, adipose tissue, spleen, thymus, adrenal glands, pancreas, cerebral cortex, and gastrointestinal tract.