MMP9

MMP9
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1GKC, 1GKD, 1ITV, 1L6J, 2OVX, 2OVZ, 2OW0, 2OW1, 2OW2, 4H1Q, 4H2E, 4H3X, 4H82, 4HMA, 4JIJ, 4JQG, 4WZV, 4XCT, 5CUH, 5I12
Identifiers
Aliases	MMP9, CLG4B, GELB, MANDP2, MMP-9, 92 kDa type IV collagenase, 92 kDa gelatinase, gelatinase B, matrix metallopeptidase 9
External IDs	OMIM: 120361; MGI: 97011; HomoloGene: 3659; GeneCards: MMP9; OMA:MMP9 - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	46,016,561 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	164,797,770 bp
RNA expression pattern
	Top expressed in
	periodontal fiber; ; trabecular bone; ; tibia; ; bone marrow; ; bone marrow cell; ; appendix; ; blood; ; cartilage tissue; ; skin of hip; ; lymph node;
	Top expressed in
	granulocyte; ; tibiofemoral joint; ; body of femur; ; Dermatocranium; ; mandible; ; bones of pectoral girdle; ; molar; ; ankle; ; rib; ; trophoblast giant cell;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	collagen binding; zinc ion binding; metal ion binding; peptidase activity; protein binding; identical protein binding; hydrolase activity; metallopeptidase activity; endopeptidase activity; serine-type endopeptidase activity; metalloendopeptidase activity;
Cellular component	extracellular matrix; extracellular exosome; extracellular space; tertiary granule lumen; ficolin-1-rich granule lumen; extracellular region; collagen-containing extracellular matrix;
Biological process	skeletal system development; negative regulation of cation channel activity; positive regulation of protein phosphorylation; endodermal cell differentiation; negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway; ossification; negative regulation of intrinsic apoptotic signaling pathway; ephrin receptor signaling pathway; extracellular matrix disassembly; negative regulation of apoptotic process; proteolysis; macrophage differentiation; positive regulation of keratinocyte migration; positive regulation of apoptotic process; collagen catabolic process; positive regulation of release of cytochrome c from mitochondria; positive regulation of receptor binding; positive regulation of DNA binding; positive regulation of epidermal growth factor receptor signaling pathway; embryo implantation; leukocyte migration; positive regulation of vascular associated smooth muscle cell proliferation; extracellular matrix organization; positive regulation of cell migration; neutrophil degranulation; cellular response to reactive oxygen species; cellular response to cadmium ion; cytokine-mediated signaling pathway; regulation of neuroinflammatory response; negative regulation of epithelial cell differentiation involved in kidney development; response to amyloid-beta;
	Sources:Amigo / QuickGO
Orthologs
	4318
	17395
	ENSG00000100985
	ENSMUSG00000017737
	P14780
	P41245
	NM_004994
	NM_013599
	NP_004985
	NP_038627
	Wikidata
View/Edit Human	View/Edit Mouse

Matrix metalloproteinase-9 (MMP-9), also known as 92 kDa type IV collagenase, 92 kDa gelatinase or gelatinase B (GELB), is a matrixin, a class of enzymes that belong to the zinc-metalloproteinases family involved in the degradation of the extracellular matrix. In humans the MMP9 gene encodes for a signal peptide, a propeptide, a catalytic domain with inserted three repeats of fibronectin type II domain followed by a C-terminal hemopexin-like domain.