GRIN1

GRIN1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2HQW, 2NR1, 3BYA, 5H8N, 5H8H, 5H8Q, 5H8F, 5I2N, 5I2K, 5KCJ, 5KDT
Identifiers
Aliases	GRIN1, GluN1, MRD8, NMDA1, NMDAR1, NR1, NMD-R1, glutamate ionotropic receptor NMDA type subunit 1, NDHMSR, NDHMSD, DEE101
External IDs	OMIM: 138249; MGI: 95819; HomoloGene: 7187; GeneCards: GRIN1; OMA:GRIN1 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	137,168,756 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	25,209,199 bp
RNA expression pattern
	Top expressed in
	right hemisphere of cerebellum; ; right frontal lobe; ; anterior cingulate cortex; ; nucleus accumbens; ; prefrontal cortex; ; Brodmann area 9; ; putamen; ; amygdala; ; caudate nucleus; ; Brodmann area 10;
	Top expressed in
	perirhinal cortex; ; entorhinal cortex; ; primary visual cortex; ; superior frontal gyrus; ; CA3 field; ; dentate gyrus of hippocampal formation granule cell; ; cerebellar cortex; ; superior colliculus; ; molecular layer of cerebellar cortex; ; primary motor cortex;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; signaling receptor binding; glycine binding; calmodulin binding; protein binding; cation channel activity; extracellularly glutamate-gated ion channel activity; glutamate binding; calcium channel activity; NMDA glutamate receptor activity; ion channel activity; ionotropic glutamate receptor activity; neurotransmitter binding; transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential; amyloid-beta binding; glutamate-gated calcium ion channel activity; signaling receptor activity; protein-containing complex binding;
Cellular component	cytoplasm; postsynaptic membrane; membrane; synapse; NMDA selective glutamate receptor complex; neuron projection; synaptic vesicle; dendritic spine; cell surface; endoplasmic reticulum; integral component of membrane; plasma membrane; postsynaptic density; integral component of plasma membrane; excitatory synapse; cell junction; dendrite; synaptic cleft; terminal bouton; postsynaptic density membrane; synaptic membrane; glutamatergic synapse; integral component of postsynaptic density membrane;
Biological process	negative regulation of neuron apoptotic process; pons maturation; synaptic transmission, glutamatergic; regulation of respiratory gaseous exchange; response to amphetamine; regulation of membrane potential; regulation of synapse assembly; learning; positive regulation of excitatory postsynaptic potential; response to ethanol; calcium ion transport; suckling behavior; prepulse inhibition; male mating behavior; regulation of long-term neuronal synaptic plasticity; adult locomotory behavior; regulation of neuron apoptotic process; ion transport; memory; regulation of axonogenesis; neuromuscular process; ionotropic glutamate receptor signaling pathway; excitatory postsynaptic potential; learning or memory; social behavior; regulation of neuronal synaptic plasticity; associative learning; startle response; calcium ion homeostasis; cation transport; cellular calcium ion homeostasis; cation transmembrane transport; respiratory gaseous exchange by respiratory system; regulation of synaptic plasticity; response to morphine; propylene metabolic process; conditioned taste aversion; cerebral cortex development; transport; sensory perception of pain; olfactory learning; regulation of cell communication; visual learning; ephrin receptor signaling pathway; MAPK cascade; regulation of dendrite morphogenesis; ion transmembrane transport; long-term memory; positive regulation of apoptotic process; positive regulation of transcription by RNA polymerase II; positive regulation of GTPase activity; calcium ion transmembrane transport; regulation of ion transmembrane transport; brain development; positive regulation of calcium ion transport into cytosol; calcium-mediated signaling; protein heterotetramerization; calcium ion transmembrane import into cytosol; excitatory chemical synaptic transmission; positive regulation of reactive oxygen species biosynthetic process; protein localization to postsynaptic membrane; cellular response to amyloid-beta; response to glycine; positive regulation of cysteine-type endopeptidase activity; regulation of NMDA receptor activity;
	Sources:Amigo / QuickGO
Orthologs
	2902
	14810
	ENSG00000176884
	ENSMUSG00000026959
	Q05586
	P35438
	NM_000832; NM_001185090; NM_001185091; NM_007327; NM_021569
NM_001177656; NM_001177657; NM_008169; NM_001372558; NM_001372559;
	NM_001372560; NM_001372561; NM_001372562
	NP_000823; NP_001172019; NP_001172020; NP_015566; NP_067544
NP_001171127; NP_001171128; NP_032195; NP_001359487; NP_001359488;
	NP_001359489; NP_001359490; NP_001359491
	Wikidata
View/Edit Human	View/Edit Mouse

Glutamate [NMDA] receptor subunit zeta-1 is a protein that in humans is encoded by the GRIN1 gene.

The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. The gene consists of 21 exons and is alternatively spliced, producing transcript variants differing in the C-terminus. The sequence of exon 5 is identical in vertebrates, with exon 5 splicing demonstrated in human, mouse and rat. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits.