GPR161

GPR161
Identifiers
Aliases	GPR161, RE2, G protein-coupled receptor 161
External IDs	OMIM: 612250; MGI: 2685054; HomoloGene: 17824; GeneCards: GPR161; OMA:GPR161 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	168,137,667 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	165,154,314 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; myometrium; ; buccal mucosa cell; ; ventricular zone; ; tail of epididymis; ; body of uterus; ; pars reticulata; ; stromal cell of endometrium; ; spinal ganglia; ; pars compacta;
	Top expressed in
	subiculum; ; otic vesicle; ; Region I of hippocampus proper; ; ganglionic eminence; ; hand; ; lumbar spinal ganglion; ; morula; ; medial ganglionic eminence; ; hippocampus proper; ; ascending aorta;
	More reference expression data
	n/a
Gene ontology
Molecular function	signal transducer activity; G protein-coupled receptor activity;
Cellular component	plasma membrane; cell projection; membrane; ciliary membrane; integral component of membrane; endocytic vesicle membrane; cilium; recycling endosome;
Biological process	multicellular organism development; signal transduction; G protein-coupled receptor signaling pathway; negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning; adenylate cyclase-activating G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	23432
	240888
	ENSG00000143147
	ENSMUSG00000040836
	Q8N6U8
	B2RPY5
NM_001267609; NM_001267610; NM_001267611; NM_001267612; NM_001267613;
	NM_001267614; NM_007369; NM_153832; NM_001349632; NM_001349633; NM_001349634; NM_001349635; NM_001375883; NM_001375884; NM_001375885; NM_001381909
	NM_001081126; NM_001310429; NM_001310430
NP_001254538; NP_001254539; NP_001254540; NP_001254541; NP_001254542;
	NP_001254543; NP_722561; NP_001336561; NP_001336562; NP_001336563; NP_001336564; NP_001362812; NP_001362813; NP_001362814; NP_001368838
	NP_001074595; NP_001297358; NP_001297359
	Wikidata
View/Edit Human	View/Edit Mouse

G-protein coupled receptor 161 is a protein that in humans is encoded by the GPR161 gene. It is located on primary cilia and regulates embryonic development through suppression of the hedgehog signaling pathway. It appears to act as a mechanoreceptor and may not require an endogenous ligand for activation.