GFI1

GFI1
Identifiers
Aliases	GFI1, GFI-1, GFI1A, SCN2, ZNF163, growth factor independent 1 transcriptional repressor
External IDs	OMIM: 600871; MGI: 103170; HomoloGene: 3854; GeneCards: GFI1; OMA:GFI1 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	92,486,925 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	107,873,902 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; bone marrow; ; bone marrow cell; ; trabecular bone; ; body of pancreas; ; testicle; ; thymus; ; blood; ; lymph node; ; spleen;
	Top expressed in
	utricle; ; vestibular sensory epithelium; ; thymus; ; saccule; ; granulocyte; ; spermatocyte; ; bone marrow; ; tongue; ; mesenteric lymph nodes; ; embryo;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; metal ion binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; protein binding; nucleic acid binding; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription factor activity;
Cellular component	nuclear body; nuclear matrix; transcription repressor complex; nucleus; nucleoplasm;
Biological process	positive regulation of interleukin-6-mediated signaling pathway; negative regulation of neuron projection development; regulation of transcription, DNA-templated; regulation of toll-like receptor signaling pathway; regulation of histone H3-K4 methylation; negative regulation of transcription by RNA polymerase II; regulation of transcription involved in G1/S transition of mitotic cell cycle; transcription, DNA-templated; negative regulation of vitamin D biosynthetic process; negative regulation of calcidiol 1-monooxygenase activity; viral process; negative regulation of transcription, DNA-templated; negative regulation of NF-kappaB transcription factor activity; cellular response to lipopolysaccharide; hemopoiesis; positive regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	2672
	14581
	ENSG00000162676
	ENSMUSG00000029275
	Q99684
	P70338
	NM_001127215; NM_001127216; NM_005263
	NM_001267621; NM_010278
	NP_001120687; NP_001120688; NP_005254
	NP_001254550; NP_034408
	Wikidata
View/Edit Human	View/Edit Mouse

Zinc finger protein Gfi-1 is a transcriptional repressor that in humans is encoded by the GFI1 gene. It is important normal hematopoiesis.