GABRA4

GABRA4
Identifiers
Aliases	GABRA4, gamma-aminobutyric acid type A receptor alpha4 subunit, gamma-aminobutyric acid type A receptor subunit alpha4
External IDs	OMIM: 137141; MGI: 95616; HomoloGene: 631; GeneCards: GABRA4; OMA:GABRA4 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	46,993,581 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	71,658,308 bp
RNA expression pattern
	Top expressed in
	postcentral gyrus; ; entorhinal cortex; ; buccal mucosa cell; ; superior frontal gyrus; ; middle temporal gyrus; ; Brodmann area 23; ; lateral nuclear group of thalamus; ; nucleus accumbens; ; endothelial cell; ; caudate nucleus;
	Top expressed in
	lateral geniculate nucleus; ; medial dorsal nucleus; ; medial geniculate nucleus; ; olfactory tubercle; ; primary motor cortex; ; cingulate gyrus; ; piriform cortex; ; anterior amygdaloid area; ; nucleus accumbens; ; globus pallidus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	ion channel activity; benzodiazepine receptor activity; chloride channel activity; extracellular ligand-gated ion channel activity; GABA-A receptor activity; transmembrane signaling receptor activity; inhibitory extracellular ligand-gated ion channel activity; GABA-gated chloride ion channel activity; transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential;
Cellular component	integral component of membrane; GABA-A receptor complex; postsynaptic membrane; membrane; synapse; integral component of plasma membrane; chloride channel complex; cell junction; plasma membrane; GABA-ergic synapse; integral component of postsynaptic specialization membrane; dendrite membrane; neuron projection; postsynapse;
Biological process	gamma-aminobutyric acid signaling pathway; chloride transmembrane transport; ion transport; regulation of response to drug; central nervous system development; chloride transport; ion transmembrane transport; signal transduction; chemical synaptic transmission; regulation of membrane potential; nervous system process; synaptic transmission, GABAergic; regulation of postsynaptic membrane potential;
	Sources:Amigo / QuickGO
Orthologs
	2557
	14397
	ENSG00000109158
	ENSMUSG00000029211
	P48169
	Q9D6F4
	NM_000809; NM_001204266; NM_001204267
	NM_010251
	NP_000800; NP_001191195; NP_001191196
NP_034381; NP_001345970; NP_001345972; NP_001345973; NP_001345974;
	NP_001345975; NP_001345976; NP_001345977; NP_001345979
	Wikidata
View/Edit Human	View/Edit Mouse

Gamma-aminobutyric acid receptor subunit alpha-4 is a protein that in humans is encoded by the GABRA4 gene.

GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified.