GABA transaminase inhibitor

GABA transaminase inhibitor
Drug class
Vigabatrin (Sabril; γ-vinyl-GABA), a selective and irreversible GABA-T inhibitor used as an anticonvulsant.
Class identifiers
SynonymsGABA-T inhibitor; GABA metabolism inhibitor; GABA degradation inhibitor
UseEpilepsy
Mechanism of actionGABA transaminase inhibition
Biological targetGABA transaminase (GABA-T)
Chemical classGABA analogues and others
Legal status
In Wikidata

A GABA transaminase inhibitor is a drug that acts as an inhibitor of the enzyme GABA transaminase (GABA-T), which metabolizes the major inhibitory neurotransmitter γ-aminobutyric acid (GABA). Inhibition of GABA-T reduces the degradation of GABA, leading to increased neuronal GABA concentrations. Examples of GABA-T inhibitors include valproic acid, vigabatrin, phenylethylidenehydrazine (PEH) (a metabolite of phenelzine), ethanolamine-O-sulfate (EOS), and L-cycloserine, among others. Certain GABA-T inhibitors, like vigabatrin, are used clinically as anticonvulsants.

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