Fumarylacetoacetic acid

Fumarylacetoacetic acid
Names
Preferred IUPAC name
(2E)-4,6-Dioxooct-2-enedioic acid
Identifiers
3D model (JSmol)
ChemSpider
MeSH Fumarylacetoacetate
UNII
  • InChI=1S/C8H8O6/c9-5(1-2-7(11)12)3-6(10)4-8(13)14/h1-2H,3-4H2,(H,11,12)(H,13,14)/b2-1+
    Key: GACSIVHAIFQKTC-OWOJBTEDSA-N
  • O=C(\C=C\C(=O)O)CC(=O)CC(=O)O
Properties
C8H8O6
Molar mass 200.146 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Fumarylacetoacetic acid (fumarylacetoacetate) is an intermediate in the metabolism of tyrosine. It is formed through the conversion of 4-maleylacetoacetic acid into fumarylacetoacetic acid by the enzyme maleylacetoacetate isomerase. Fumarylacetoacetic acid is hydrolyzed by the enzyme fumarylacetoacetate hydrolase (FAH), producing acetoacetate and fumarate. These compounds may then enter various other metabolic pathways.

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