Fries rearrangement

Fries rearrangement
Named after Karl Theophil Fries
Reaction type Rearrangement reaction
Identifiers
Organic Chemistry Portal fries-rearrangement
RSC ontology ID RXNO:0000444

The Fries rearrangement, named for the German chemist Karl Theophil Fries, is a rearrangement reaction of a phenolic ester to a keto phenol. The reaction is induced by a Lewis acid. It involves migration of an acyl group of phenol ester to the aryl ring. The reaction is ortho and para selective and one of the two products can be favoured by changing reaction conditions, such as temperature and solvent. In some cases, the reaction is conducted with no solvent.

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