Formiminoglutamic acid

Formiminoglutamic acid
Names
IUPAC name
N-(aminomethylidene)-L-glutamic acid
Other names
FIGLU
Identifiers
3D model (JSmol)
ChemSpider
ECHA InfoCard 100.011.308
MeSH Formiminoglutamic+acid
UNII
  • InChI=1S/C6H10N2O4/c7-3-8-4(6(11)12)1-2-5(9)10/h3-4H,1-2H2,(H2,7,8)(H,9,10)(H,11,12)
    Key: NRXIKWMTVXPVEF-UHFFFAOYSA-N
  • C(CC(=O)O)C(C(=O)O)N=CN
Properties
C6H10N2O4
Molar mass 174.156 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Formiminoglutamic acid (FIGLU; conjugate base, formiminoglutamate) is an intermediate in the catabolism of L-histidine to L-glutamic acid. It thus is also a biomarker for intracellular levels of folate. The FIGLU test is used to identify vitamin B12 deficiency, folate deficiency, and liver failure or liver disease. It is elevated with folate trapping, where it is accompanied by decreased methylmalonic acid, increased folate and a decrease in homocysteine.

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