Folate receptor

Folate receptor family
Identifiers
SymbolFolate_rec
PfamPF03024
InterProIPR004269
Available protein structures:
PDB  IPR004269 PF03024 (ECOD; PDBsum)  
AlphaFold

Folate receptors bind folate and reduced folic acid derivatives and mediate delivery of tetrahydrofolate to the interior of cells. It is then converted from monoglutamate to polyglutamate forms - such as 5-methyltetrahydrofolate - as only monoglutamate forms can be transported across cell membranes. Polyglutamate forms are biologically active enzymatic cofactors required for many folate-dependent processes such as folate-dependent one-carbon metabolism. These proteins are attached to the membrane by a GPI anchor. A riboflavin-binding protein required for the transport of riboflavin to the developing oocyte in chicken also belong to this family.

Human proteins from this family include:

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