Favorskii rearrangement

Not to be confused with Favorskii reaction.

Favorskii rearrangement
Named after Alexei Yevgrafovich Favorskii
Reaction type Rearrangement reaction
Identifiers
Organic Chemistry Portal favorsky-reaction
RSC ontology ID RXNO:0000385

In organic chemistry, the Favorskii rearrangement is a reaction of α-halo ketones with a nucleophilic base to acyl derivatives. In the rearrangement, the substrate extrudes the carbonyl carbon to a primary position, which then acylates the base. In the case of cyclic α-halo ketones, the Favorskii rearrangement constitutes a ring contraction:

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