| FASN |
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| Identifiers |
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| Aliases | FASN, fatty acid synthase, Fasn, A630082H08Rik, FAS, OA-519, SDR27X1, Fatty acid synthase |
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| External IDs | OMIM: 600212; MGI: 95485; HomoloGene: 55800; GeneCards: FASN; OMA:FASN - orthologs |
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| Gene location (Mouse) |
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| | Chr. | Chromosome 11 (mouse) |
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| | Band | 11 E2|11 84.56 cM | Start | 120,696,672 bp |
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| End | 120,715,373 bp |
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| RNA expression pattern |
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| Bgee | | Human | Mouse (ortholog) |
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| Top expressed in | - right hemisphere of cerebellum
- skin of abdomen
- skin of leg
- abdominal fat
- anterior pituitary
- right lobe of liver
- nipple
- subcutaneous adipose tissue
- right frontal lobe
- right lung
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| | Top expressed in | - tunica adventitia of aorta
- lactiferous gland
- subcutaneous adipose tissue
- tunica media of zone of aorta
- brown adipose tissue
- white adipose tissue
- trachea
- superior surface of tongue
- intercostal muscle
- parotid gland
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| | More reference expression data |
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| BioGPS | |
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| Wikidata |
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Fatty acid synthase (FAS) is an enzyme that in humans is encoded by the FASN gene.
Fatty acid synthase is a multi-enzyme protein that catalyzes fatty acid synthesis. It is not a single enzyme but a whole enzymatic system composed of two identical 272 kDa multifunctional polypeptides, in which substrates are handed from one functional domain to the next.
Its main function is to catalyze the synthesis of palmitate (C16:0, a long-chain saturated fatty acid) from acetyl-CoA and malonyl-CoA, in the presence of NADPH.
The fatty acids are synthesized by a series of decarboxylative Claisen condensation reactions from acetyl-CoA and malonyl-CoA. Following each round of elongation the beta keto group is reduced to the fully saturated carbon chain by the sequential action of a ketoreductase (KR), dehydratase (DH), and enoyl reductase (ER). The growing fatty acid chain is carried between these active sites while attached covalently to the phosphopantetheine prosthetic group of an acyl carrier protein (ACP), and is released by the action of a thioesterase (TE) upon reaching a carbon chain length of 16 (palmitic acid).