Frizzled-4

FZD4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	5BPB, 5BPQ, 5BQC, 5BQE, 5CL1, 5CM4
Identifiers
Aliases	FZD4, CD344, EVR1, FEVR, FZD4S, Fz-4, Fz4, FzE4, GPCR, hFz4, frizzled class receptor 4
External IDs	OMIM: 604579; MGI: 108520; HomoloGene: 7325; GeneCards: FZD4; OMA:FZD4 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	86,955,395 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	89,062,342 bp
RNA expression pattern
	Top expressed in
	adipose tissue; ; subcutaneous adipose tissue; ; right lung; ; abdominal fat; ; parietal pleura; ; synovial joint; ; tendon of biceps brachii; ; pericardium; ; seminal vesicula; ; thoracic diaphragm;
	Top expressed in
	retinal pigment epithelium; ; choroid plexus of fourth ventricle; ; ciliary body; ; internal carotid artery; ; Epithelium of choroid plexus; ; epithelium of stomach; ; ankle; ; subcutaneous adipose tissue; ; white adipose tissue; ; external carotid artery;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	PDZ domain binding; protein homodimerization activity; signal transducer activity; protein binding; protein heterodimerization activity; Wnt-activated receptor activity; ubiquitin protein ligase binding; transmembrane signaling receptor activity; cytokine binding; G protein-coupled receptor activity; Wnt-protein binding; amyloid-beta binding; signaling receptor activity; protein-containing complex binding;
Cellular component	clathrin-coated endocytic vesicle membrane; membrane; cell-cell junction; plasma membrane; integral component of plasma membrane; cell surface; extracellular exosome; integral component of membrane; clathrin-coated vesicle membrane; dendrite; synapse; glutamatergic synapse;
Biological process	negative regulation of cell-substrate adhesion; cellular response to retinoic acid; G protein-coupled receptor signaling pathway; luteinization; extracellular matrix-cell signaling; positive regulation of JUN kinase activity; positive regulation of DNA-binding transcription factor activity; hearing; Wnt signaling pathway; regulation of vascular endothelial growth factor receptor signaling pathway; vasculogenesis; positive regulation of transcription, DNA-templated; multicellular organism development; cerebellum vasculature morphogenesis; cell surface receptor signaling pathway; progesterone secretion; blood vessel development; neuron differentiation; retinal blood vessel morphogenesis; canonical Wnt signaling pathway; substrate adhesion-dependent cell spreading; locomotion involved in locomotory behavior; retina vasculature morphogenesis in camera-type eye; signal transduction; Wnt signaling pathway, calcium modulating pathway; Wnt signaling pathway, planar cell polarity pathway; membrane organization; non-canonical Wnt signaling pathway; positive regulation of neuron projection arborization; cellular response to leukemia inhibitory factor;
	Sources:Amigo / QuickGO
Orthologs
	8322
	14366
	ENSG00000174804
	ENSMUSG00000049791
	Q9ULV1
	Q61088
	NM_012193
	NM_008055
	NP_036325
	NP_032081
	Wikidata
View/Edit Human	View/Edit Mouse

Frizzled-4 (Fz-4) is a protein that in humans is encoded by the FZD4 gene. Fz-4 has also been designated as CD344 (cluster of differentiation 344).