FRRS1L

FRRS1L
Identifiers
Aliases	FRRS1L, C9orf4, CG-6, CG6, ferric chelate reductase 1 like, EIEE37, DEE37
External IDs	OMIM: 604574; MGI: 2442704; HomoloGene: 87703; GeneCards: FRRS1L; OMA:FRRS1L - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	109,167,249 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	56,990,391 bp
RNA expression pattern
	Top expressed in
	middle temporal gyrus; ; Brodmann area 23; ; orbitofrontal cortex; ; frontal pole; ; postcentral gyrus; ; Brodmann area 10; ; superior frontal gyrus; ; paraflocculus of cerebellum; ; entorhinal cortex; ; endothelial cell;
	Top expressed in
	cerebellar vermis; ; lobe of cerebellum; ; primary motor cortex; ; Region I of hippocampus proper; ; prefrontal cortex; ; cingulate gyrus; ; amygdala; ; medial geniculate nucleus; ; anterior amygdaloid area; ; lateral geniculate nucleus;
	More reference expression data
	n/a
Gene ontology
Molecular function	molecular function;
Cellular component	integral component of membrane; cell junction; plasma membrane; synapse; membrane; cellular component;
Biological process	regulation of glutamate receptor signaling pathway; regulation of postsynaptic membrane neurotransmitter receptor levels;
	Sources:Amigo / QuickGO
Orthologs
	23732
	230235
	ENSG00000260230
	ENSMUSG00000045589
	Q9P0K9
	B1AXV0
	NM_014334
	NM_001142965
	NP_055149
	NP_001136437
	Wikidata
View/Edit Human	View/Edit Mouse

Ferric chelate reductase 1-like is a protein that in humans is encoded by the FRRS1L gene. This protein makes up part of a type of AMPA receptor involved in communication between cells in the brain. Loss-of-function mutations to FRRS1L are associated with early infantile epilepsy, developmental delay, progressive dyskinesia, diffuse hypotonia, and global loss of function.