FOXM1

FOXM1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3G73
Identifiers
Aliases	FOXM1, FKHL16, FOXM1B, HFH-11, HFH11, HNF-3, INS-1, MPHOSPH2, MPP-2, MPP2, PIG29, TGT3, TRIDENT, forkhead box M1, FOXM1A, FOXM1C
External IDs	OMIM: 602341; MGI: 1347487; HomoloGene: 7318; GeneCards: FOXM1; OMA:FOXM1 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	2,877,174 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	128,353,109 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; ganglionic eminence; ; gonad; ; sperm; ; mucosa of transverse colon; ; left testis; ; stromal cell of endometrium; ; right testis; ; testicle; ; rectum;
	Top expressed in
	genital tubercle; ; tail of embryo; ; ventricular zone; ; secondary oocyte; ; zygote; ; otic vesicle; ; primary oocyte; ; otic placode; ; yolk sac; ; seminiferous tubule;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; sequence-specific DNA binding; DNA-binding transcription factor activity; protein binding; protein kinase binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus; nucleoplasm;
Biological process	positive regulation of double-strand break repair; regulation of Ras protein signal transduction; negative regulation of transcription by RNA polymerase II; regulation of reactive oxygen species metabolic process; transcription by RNA polymerase II; transcription, DNA-templated; regulation of cell cycle; cellular response to DNA damage stimulus; regulation of cell population proliferation; G2/M transition of mitotic cell cycle; regulation of cell growth; positive regulation of cell population proliferation; negative regulation of stress-activated MAPK cascade; negative regulation of transcription, DNA-templated; DNA repair; positive regulation of transcription by RNA polymerase II; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; regulation of transcription, DNA-templated; anatomical structure morphogenesis; cell differentiation; cell cycle; positive regulation of transcription, DNA-templated;
	Sources:Amigo / QuickGO
Orthologs
	2305
	14235
	ENSG00000111206
	ENSMUSG00000001517
	Q08050
	O08696
	NM_001243088; NM_001243089; NM_021953; NM_202002; NM_202003
	NM_008021
	NP_001230017; NP_001230018; NP_068772; NP_973731; NP_973732
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Forkhead box protein M1 is a protein that in humans is encoded by the FOXM1 gene. The protein encoded by this gene is a member of the FOX family of transcription factors. Its potential as a target for future cancer treatments led to it being designated the 2010 Molecule of the Year.