FLVCR2

FLVCR2
Identifiers
Aliases	FLVCR2, C14orf58, CCT, EPV, FLVCRL14q, MFSD7C, PVHH, feline leukemia virus subgroup C cellular receptor family member 2, SLC49A2, FLVCR heme transporter 2
External IDs	OMIM: 610865; MGI: 2384974; HomoloGene: 9840; GeneCards: FLVCR2; OMA:FLVCR2 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	75,663,214 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	85,860,359 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; tibial nerve; ; monocyte; ; sperm; ; right testis; ; left testis; ; right adrenal cortex; ; left adrenal cortex; ; mucosa of ileum; ; right lobe of liver;
	Top expressed in
	retinal pigment epithelium; ; morula; ; morula; ; blastocyst; ; yolk sac; ; spermatid; ; proximal tubule; ; right kidney; ; spermatocyte; ; seminiferous tubule;
	More reference expression data
	n/a
Gene ontology
Molecular function	heme transmembrane transporter activity; heme binding;
Cellular component	integral component of membrane; plasma membrane; membrane;
Biological process	transmembrane transport; heme transport; heme export;
	Sources:Amigo / QuickGO
Orthologs
	55640
	217721
	ENSG00000119686
	ENSMUSG00000034258
	Q9UPI3
	Q91X85
	NM_017791; NM_001195283
	NM_145447
	NP_001182212; NP_060261
	NP_663422
	Wikidata
View/Edit Human	View/Edit Mouse

Feline leukemia virus subgroup C cellular receptor family, member 2 (FLVCR2) is a choline transporter belonging to the major facilitator superfamily (MFS). It is a uniporter transmembrane protein that transports choline across the plasma membrane via a concentration gradient. FLVCR2 is highly enriched in endothelial cells of the blood-brain barrier but is also expressed in peripheral tissues such as the small intestine where it absorbs dietary choline. At the blood-brain barrier, FLVCR2 is the primary transporter of choline responsible for approximately 60% of the brains supply.

Mutations in FLVCR2 have been associated with proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome (Fowler syndrome).